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Sarkis Mazmanian

American microbiologist

Sarkis Mazmanian is an American medical microbiologist who has served as a professor at the California Institute of Technology since He is currently the Luis & Nelly Soux Professor of Microbiology in the Division of Biology and Biological Engineering, and a board member of Seed.

Prior to this, Mazmanian was affiliated with Harvard Medical School and the University of Chicago. In , Mazmanian was awarded a MacArthur Fellowship for his pioneering work on the human microbiome.

Sarkis mazmanian biography examples Sarkis Mazmanian is an American medical microbiologist who has served as a professor at the California Institute of Technology since He is currently the Luis & Nelly Soux Professor of Microbiology in the Division of Biology and Biological Engineering, and a board member of Seed.

Work

Mazmanian's research investigates the symbiotic relationship between beneficial bacteria and their hosts. In seminal work, Mazmanian discovered the first microbial molecule that has direct beneficial effects on mammals. Working in Dennis Kasper's lab, he showed in that a particular bacterial species, Bacteroides fragilis, from the human microbiome augments immune function and balances a dysregulated immune system.[1] Mazmanian has described and defined a novel paradigm in science whereby the gut microbiome intricately controls the development and function of the mammalian immune system.

These discoveries include the demonstration that B. fragilis can treat experimental inflammatory bowel disease by inducing the activity of protective, regulatory immune cells. Further, his laboratory revealed that the gut microbiome impacts autoimmune diseases such as experimental multiple sclerosis.

Mazamanian has also been involved in several ventures, having founded Axial Biotherapeutics and Symbiotix Biotherapies.

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  • Axial aimed to 'microbiota analysis to better understand the relationship between microbes and the central nervous system', and raised $m with early investors including Longwood Fund.[2][3][4][5]The New York Times noted Symbiotix as 'developing a complex sugar called PSA, which is associated with Bacteroides fragilis, into treatments for intestinal disease and multiple sclerosis'.[6] He also serves on the scientific advisory board of over a dozen companies, academic centers and not-for-profit foundations.

    Personal life

    Mazamanian was born in Lebanon to two Armenian refugees, moving to the US in whilst a toddler. He enrolled at UCLA in , planning to major in English, before focusing on microbiology. He graduated in having majored in microbiology, before enrolling on a PHD which he concluded in [7] He was awarded a Helen Hay Whitney Postdoctoral Fellowship at Harvard Medical School, before moving to Caltech in , where he established the microbiome department.[8]

    Mazmanian's research has won him several awards including a Searle Scholar, Young Investigator of the Year at Harvard Medical School, Damon Runyon Innovation Award, the MacArthur Foundation Award, and Discover Magazine named him as one of the "Best Brains in Science under 40".[9]

    References

    1. ^Mazmanian SK, Liu CH, Tzianabos AO, Kasper DL ().

      "An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system". Cell.

      Sarkis mazmanian biography examples in english Immunologic and neurologic imbalances underlie many diseases. The human body represents a scaffold upon which multitudes of commensal species build residence, creating a diverse ecosystem with members of five of the six kingdoms of life.

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    2. ^Adams, Susan. "Drugs From Bugs: Why Gates, Zuck And Benioff Think The Next Blockbusters Will Come From Inside Your Gut". Forbes. Retrieved
    3. ^Quaglia, Sofia.

      "How your microbiome can improve your health". . Retrieved

    4. ^Lee, Yeji Jesse.

    5. Sarkis K. Mazmanian's research works | California Institute ...
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    7. Details
    8. BRAIN PI: Sarkis Mazmanian - The BRAIN Foundation
    9. Sarkis K Mazmanian - The Autism Community in Action
    10. "Meet the 10 neuroscience startups that have raised millions to treat mental health and cure neurologic diseases". Business Insider. Retrieved

    11. ^Martino, Cameron; Zaramela, Livia S.; Gao, Bei; Embree, Mallory; Tarasova, Janna; Parker, Seth J.; Wang, Yanhan; Chu, Huikuan; Chen, Peng; Lee, Kuei-Chuan; Galzerani, Daniela Domingos; Gengatharan, Jivani M.; Lekbua, Asama; Neal, Maxwell; Knight, Rob ().

      "Acetate reprograms gut microbiota during alcohol consumption". Nature Communications. 13 (1): BibcodeNatCoM.

      Short biography examples Sarkis Mazmanian received a B.S. () and a Ph.D. () from the University of California at Los Angeles. Prior to joining the faculty of the California Institute of Technology in , where he is currently a professor in the Division of Biology, he was affiliated with the University of Chicago (–) and Harvard Medical School (

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    12. ^Smith, Peter Andrey (). "Can the Bacteria in Your Gut Explain Your Mood?". The New York Times. ISSN&#; Retrieved
    13. ^"Autism's Gut Connection: Microbes Could Soon Lead to New Treatments". Discover Magazine. Retrieved
    14. ^"uBiome Appoints Dr.

      Sarkis K. Mazmanian, PhD, MacArthur Genius and Luis & Nelly Soux Professor of Microbiology at Caltech, to its Scientific Advisory Board".

      Sarkis mazmanian biography examples wikipedia

      Sarkis Mazmanian is an American medical microbiologist who has served as a professor at the California Institute of Technology since He is currently the Luis & Nelly Soux Professor of Microbiology in the Division of Biology and Biological Engineering, and a board member of Seed.

      . Retrieved

    15. ^"uBiome Appoints Dr. Sarkis K. Mazmanian, PhD, MacArthur Genius and Luis & Nelly Soux Professor of Microbiology at Caltech, to its Scientific Advisory Board". PRWeb. Retrieved